Kunwarvir Singh1*, Renu Chaudhary2, Anu3 Jitendra Singh4, Dipti5 and Ashish Tomar6
1Department of Chemistry, N. R. E. C. College, Khurja (U.P.)
2Department of School of Biosciences, I.M.S. College, Ghaziabad (U.P.)
3Department of Chemistry, R.G. (P.G.) College, Meerut (U.P.)
4,5,6Department of Chemistry, Meerut College, Meerut (U.P.)
Email: singh.veer009@gmail.com
Received-07.11.2014, Revised-28.12.2014
Abstract: Two series of novel chalcones (4a-4g, 5a-5g) have been synthesized by solution phase Claisen-Schmidt condensation. All the new final products have been purified by silica gel column chromatograpgy and characterized on the basis of their infrared (IR) and proton nuclear magnetic resonance (1H NMR) spectroscopic data, and elemental analysis. All the final compounds (4-5) were exploited for their antimicrobial activity by the cup-plate method. From the antibacterial screening it was observed that the compounds, 4 (a, d, f and g ), 5 (b, c, d, e and f), shows good antibacterial activity against Staphylococcus aureus (zone of inhibition,10-16 mm) as compared to standard streptomycin (zone of inhibition, 18 mm)whereas compounds 4 (a and b), 5 (b, c and d), showed good antibacterial activity against Escherichia coli (zone of inhibition,10-18 mm) as compared to streptomycin (zone of inhibition, 22 mm). Fungicidal screening data also revealed that compounds 4 (b and d), 5 (a and e), imparted maximum activity against Aspergillus niger (zone of inhibition, 10-15 mm) as compared to standard griesofulvin (zone of inhibition, 17 mm), whereas compounds 4 (b, c, f and g), 5b, showed good activity against Candida albicans (zone of inhibition, 10-16 mm) as compared to griesofulvin (zone of inhibition, 20 mm).
Keywords: Chalcones, Condensation, Antimicrobial activity
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