Blanca Liliana Sánchez-Rodríguez1,2, David Pedroza-Escobar*1, Lisset-Esmeralda González-Manjarrez2, Alejandra Torres-Flores2, Irais Castillo-Maldonado1, DealmyDelgadillo-Guzmán2, Tania González-Cortés1, Cecilia Hernández-Morales3, Pedro IV González-Luna3, Erika Flores-Loyola4, Agustina Ramírez-Moreno4, Joaquín Avalos-Soto5 and Miguel Ángel Téllez-López5
1Centro de Investigacion Biomedica. Universidad Autonoma de Coahuila. Unidad Laguna.
Torreon, Coahuila, 27000, Mexico
2Facultad de Medicina. Universidad Autonoma de Coahuila. Unidad Laguna.
Torreon, Coahuila, 27000, Mexico
3Facultad de Odontologia. Universidad Autonoma de Coahuila. Unidad Laguna.
Torreon, Coahuila, 27000, Mexico
4Facultad de Ciencias Biologicas, Unidad Laguna. Torreon, Coahuila, 27087, Mexico
5Cuerpo Académico Farmacia y Productos Naturales, Facultad de Ciencias Químicas,
Universidad Juárez del Estado de Durango, Gómez Palacio, Mexico.
Email: dpedroza@uadec.edu.mx
Received-02.02.2025, Revised-15.02.2025, Accepted-28.02.2025
Abstract: Phytocompounds are naturally occurring bioactive molecules synthesized by plants that have demonstrated diverse pharmacological properties, including immunomodulatory effects. These compounds are classified into several categories such as polyphenols, alkaloids, saponins, terpenoids, glycosides, and phytosterols. Phytocompounds can modulate immune responses through mechanisms involving cytokine regulation, immune cell activation, enhancement of antigen presentation, and modulation of inflammatory signaling pathways. This review aims to provide a comprehensive overview of the immunomodulatory properties of several notable phytocompounds, including quercetin, tannic acid, curcumin, vincristine, Quillaja saponaria, ginsenosides, betulinic acid, and resveratrol. The therapeutic potential of these compounds is described in contexts such as vaccine adjuvants, treatment of autoimmune and inflammatory disorders, cancer therapy, and infectious disease management. Despite their promising biological activities, challenges remain in terms of standardization, bioavailability, and understanding of their precise mechanisms of action. Future research should focus on improving phytocompound formulations, elucidating their immunomodulatory mechanisms, and conducting rigorous clinical trials to optimize their therapeutic applications.
Keywords: Phytocompounds, Immunomodulation, Curcumin, Vincristine, Quillaja saponaria, Ginsenosides, Resveratrol
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