Veena Sharma*, Ritu Paliwal and Lokendra Singh#
Department of Bioscience and Biotechnology, Banasthali University,
Banasthali-304022, Rajasthan, India
#Department of Botany, Meerut College Meerut
E-mail: drvshs@gmail.com, paliwal.ritu18@gmail.com
Abstract: The present investigation was carried out to elucidate anticarcinogenic potential of hydro-ethanolic extract of M. oleifera (MOHE) and its isolated saponin (SM) in attenuatuation of 7, 12-dimethylbenz[a]anthracene (DMBA) induced hepatocarcinogenesis in male mice. Single oral administration of DMBA (15 mg/kg) to mice resulted in elevated levels of xenobiotic enzymes, hepatic malondialdehyde, with reduction in hepatic glutathione content, superoxide dismutase, catalase and phase-II metabolizing enzymes such as glutathione-S-transferase. The status of hepatic biochemical markers and total protein content were also found to be decreased along with increase in total cholesterol in DMBA administered mice. Pretreatment with the Moringa oleifera and its isolated saponin orally for 21 days offered almost complete protection against DMBA induced tissue toxicity. The current investigation supports Moringa oleifera and its isolated saponin as a potent chemopreventive agent and suppresses DMBA-induced hepatic carcinogenesis in mice that might be due to decreased free radical generation.
Keywords: Moringa oleifera; 7, 12 dimethyl benz[a]anthracene, hepatocarcinogenesis; saponin, xenobiotic, mice
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