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Alejandra Torres-Flores1,2, Ana-Lucia Novelo-Aguirre1,2, Sofia-Joseline Sandoval-Villagrana1,2, Tania González-Cortés2, Iraís Castillo-Maldonado2, Dealmy Delgadillo-Guzmán1, Cecilia Hernández-Morales3, Agustina Ramirez-Moreno4, Erika Flores-Loyola4, Joaquín Avalos-Soto5, Miguel Ángel Téllez-López5, Gladis Michel-Ramírez2 and David Pedroza-Escobar*2
1Facultad de Medicina. Universidad Autonoma de Coahuila. Unidad Laguna. Torreon, Coahuila, 27000, Mexico., 2Centro de Investigacion Biomedica. Universidad Autonoma de Coahuila. Unidad Laguna. Torreon, Coahuila, 27000, Mexico., 3Facultad de Odontologia. Universidad Autonoma de Coahuila. Unidad Laguna. Torreon, Coahuila, 27000, Mexico., 4Facultad de Ciencias Biológicas. Universidad Autonoma de Coahuila. Unidad Laguna. Torreón, Coahuila, 27275, Mexico. 5Cuerpo Académico Farmacia y Productos Naturales, Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Gómez Palacio, Mexico
Email: dpedroza@uadec.edu.mx
Received-28.04.2026, Revised-14.05.2026, Accepted-30.05.2026
Abstract: Trans-resveratrol is a polyphenol that belongs to the stilbene family. In nature, resveratrol works primarily as a phytoalexin., it is synthesized by more than 70 plant species as a primary defense mechanism against environmental stressors, such as prolonged exposure to ultraviolet radiation or fungal and bacterial infections. Among the richest botanical sources is the Vitis vinifera plant whose fruits store this compound mainly in the skin of the grapes. Berries, blueberries and cranberries are a known source of resveratrol. Polygonum cuspidatum is a plant used as a source of resveratrol extraction for use in dietary supplements. Other sources of resveratrol include various trees like eucalyptus and floral species such as lilies. Several studies have documented different medicinal effects of resveratrol on human health, including its antioxidant, anti-inflammatory, cardioprotective, and neuroprotective properties. For human consumption, this antioxidant is available in a variety of everyday foods, especially red and purple fruits, peanuts, grapes and red wine. The maceration process of red wine, which includes the skin, seeds, and woody parts of the plant, facilitates a very high concentration of this compound, giving it great nutritional value. On a structural level, resveratrol is composed of two aromatic rings linked by a carbon-carbon double bond, allowing it to exist in cis and trans configurations. The trans form is the most stable and, therefore, the most used in health research. Its synthesis occurs through three condensation reactions mediated by the enzyme stilbene synthase. Conclusions: Trans-resveratrol is a naturally occurring polyphenolic stilbene synthesized by numerous plant species as part of their defense mechanisms against environmental stress conditions. It is found in human foods such as grapes, berries, peanuts, and red wine. Several studies have documented its potential benefits for human health.
Keywords: Medicinal properties, Resveratrol, Stilbene, Phenolics, Trans-resveratrol
REFERENCES
Bonnefont-Rousselot, D. (2016). Resveratrol and cardiovascular diseases. Nutrients, 8(5), 250. https://doi.org/10.3390/nu8050250
Chiou, YS., Tsai, ML., Nagabhushanam, K., Wang, YJ., Wu, CH., Ho, CT. and Pan, MH (2011).Pterostilbene is more potent than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling pathway. J Agric Food Chem. 2011 Mar 23.,59(6):2725-33. doi: 10.1021/jf2000103. Epub Feb 28. PMID: 21355597.
Christovam, AC., Theodoro, V., Mendonça, FAS., Esquisatto, MAM., Dos Santos, GMT. and do Amaral, MEC (2019). Activators of SIRT1 in wound repair: an animal model study. Arch Dermatol Res. Apr.,311(3):193-201. doi: 10.1007/s00403-019-01901-4. Epub 2019 Feb 19. PMID: 30783767.
Cui, B., Wang, Y., Jin, J., Yang, Z., Guo, R., Li, X., Yang, L. and Li, Z. (2022).Resveratrol Treats UVB-Induced Photoaging by Anti-MMP Expression, through Anti-Inflammatory, Antioxidant, and Antiapoptotic Properties, and Treats Photoaging by Upregulating VEGF-B Expression. Oxidative Medicine and Cellular Longevity, 2022. https://doi.org/10.1155/2022/6037303
Draczynska-Lusiak, B., Doung, A. and Sun, A. Y. (1998). Oxidized lipoproteins may play a role in neuronal cell death in Alzheimer disease. Molecular and chemical neuropathology, 33(2), 139–148. https://doi.org/10.1007/BF02870187
Fernández-Tresguerres, I., Tamimi, F., Eimar, H., Barralet, J., Torres, J., Blanco, L. and Tresguerres, J. A. F. (2014). Resveratrol as anti-aging therapy for age-related bone loss. Rejuvenation Research, 17(5), 439–445. https://doi.org/10.1089/rej.2014.1551
Frémont, L. (2000). Biological effects of resveratrol. Life Sciences, 66(8), 663–673. https://doi.org/10.1016/s0024-3205(99)00410-5
Gal, R., Deres, L., Toth, K., Halmosi, R. and Habon, T. (2021). The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results. International Journal of Molecular Sciences, 22(18), 10152. https://doi.org/10.3390/ijms221810152
Gambini, J., López-Grueso, R., Olaso-González, G., Inglés, M., Abdelazid, K., Alami, M. E., Bonet-Costa, V., Borrás, C. and Viña, J.(2013). Resveratrol: distribución, propiedades y perspectivas. Revista Española De Geriatría Y Gerontología, 48(2), 79–88. https://doi.org/10.1016/j.regg.2012.04.007
García Meijide, J. A. and Gómez-Reino Carnota, J. J. (2000). Fisiopatología de la ciclooxigenasa-1y ciclooxigenasa-2. Revista Española de Reumatología, 27(1).https://www.elsevier.es/es-revista-revista-espanola-reumatologia-29-articulo-fisiopatologia-ciclooxigenasa-1-ciclooxigenasa-2-8546
Hecker, A., Schellnegger., M., Hofmann, E., Luze, H., Nischwitz, SP., Kamolz, LP. and Kotzbeck, P.(2022). The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J. Jan.,19(1):9-28. doi: 10.1111/iwj.13601. Epub 2021 May 5. PMID: 33949795., PMCID: PMC8684849.
Herold, K. and Mrowka, R.(2019).“Inflammation – dysregulated inflammatory response and strategies for treatment”, Acta Physiologica, 226(3):1-4.
Huang X, Sun J, Chen G, Niu C, Wang Y, Zhao C, Sun J, Huang H, Huang S, Liang Y, Shen Y, Cong W, Jin L. and Zhu Z. (2019).Resveratrol Promotes Diabetic Wound Healing via SIRT1-FOXO1-c-Myc Signaling Pathway-Mediated Angiogenesis. Front. Pharmacol. 10:421. doi: 10.3389/fphar.2019.00421
Kawada, N., Seki, S., Inoue, M. and Kuroki, T.(1998). Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology (Baltimore, Md.), 27(5), 1265–1274. https://doi.org/10.1002/hep.510270512
Khanna, S., Venojarvi, M., Roy, S., Sharma, N., Trikha, P., Bagchi, D., Bagchi, M. and Sen, CK.(2002). Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med. 15.,33(8):1089-96. doi: 10.1016/s0891-5849(02)00999-1. PMID: 12374620.
Koushki, M., Amiri-Dashatan, N.., Ahmadi, N., Abbaszadeh, H. A. and Rezaei-Tavirani, M.(2018). Resveratrol: A miraculous natural compound for diseases treatment. In Food Science and Nutrition (Vol. 6) Issue 8, pp. 2473–2490 Wiley-Blackwell. https://doi.org/10.1002/fsn3.855
Kumar, RJ., Jyostna, D., Krupadanam, GL. and Srimannarayana, G.(1988). Phenanthrene and stilbenes from Pterolobium hexapetallum. Phytochemistry. 27(2).
Liang, Y., Chen, X., Teng, Z., Wang, X., Yang, J. and Liu, G.(2024). Discovery of a 4-Hydroxy-3′-Trifluoromethoxy-Substituted Resveratrol Derivative as an Anti-Aging Agent. Molecules, 29(1). https://doi.org/10.3390/molecules29010086
Malaguarnera L.(2019). Influence of Resveratrol on the Immune Response. Nutrients. 11(5):946. doi: 10.3390/nu11050946. PMID: 31035454., PMCID: PMC6566902.
Maier-Salamon, A., Böhmdorfer, M., Thalhammer, T., Szekeres, T. and Jaeger, W.(2011). Hepatic glucuronidation of resveratrol: Interspecies comparison of enzyme kinetic profiles in human, mouse, rat, and dog. Drug Metabolism and Pharmacokinetics, 26(4), 364–373. https://doi.org/10.2133/dmpk.dmpk-11-rg-006
Martínez-Canabal, A. and Rivas-Arancibia, S.(2005). Funciones de las prostaglandinas en el sistema nervioso central. Revista de La Facultad de Medicina, 48(5), 210–216.https://www.medigraphic.com/pdfs/facmed/un-2005/un055i.pdf
Meng, T., Xiao, D., Muhammed, A., Deng, J., Chen, L. and He, J.(2021). “Anti-Inflammatory Action and Mechanisms of Resveratrol”, Molecules, 26(229):1.15.
Niño Sánchez, A., Medellín Guerrero, A. B., Solís Pérez, E., López-Cabanillas Lomelí, M. and Méndez López, L. F.(2025).Biotransformación del resveratrol y afinidad por COX-2: análisis in silico del potencial antiinflamatorio. RESPYN Revista Salud Pública Y Nutrición, 24(3), 18–26. https://doi.org/10.29105/respyn24.3-885
Perrone, D., Fuggetta, M. P., Ardito, F., Cottarelli, A., de Filippis, A., Ravagnan, G., de Maria, S. and lo Muzio, L.(2017). Resveratrol (3,5,4’-Trihydroxystilbene) and its properties in oral diseases (Review). In Experimental and Therapeutic Medicine (Vol. 14, Issue 1, pp. 3–9). Spandidos Publications. https://doi.org/10.3892/etm.2017.4472
Rahman, M. H., Akter, R., Bhattacharya, T., Abdel-Daim, M. M., Alkahtani, S., Arafah, M. W., Al-Johani, N. S., Alhoshani, N. M., Alkeraishan, N., Alhenaky, A., Abd-Elkader, O. H., El-Seedi, H. R., Kaushik, D. and Mittal, V.(2020). Resveratrol and neuroprotection: Impact and its therapeutic potential in Alzheimer’s disease. Frontiers in Pharmacology, 11, Artículo 619024. https://doi.org/10.3389/fphar.2020.619024
Roshani, M., Jafari, A., Loghman, A., Sheida, AH., Taghavi, T., Tamehri, Zadeh, SS., Hamblin, MR., Homayounfal, M. and Mirzaei, H.(2022).Applications of resveratrol in the treatment of gastrointestinal cancer. Biomed Pharmacother. 153:113274. doi: 10.1016/j.biopha.2022.113274. Epub 2022 Jun 18. PMID: 35724505.
Sánchez-Nieto, J, M., Sierra-Zurita, D. I., Ruiz-Ramos, M. and Mendoza-Núñez, V. M.(2023). Efecto del resveratrol sobre las funciones cognitivas en adultos mayores: una revisión sistemática y metaanálisis. Nutrición Hospitalaria, 40(6), 1253-1261. https://doi.org/10.20960/nh.04479
Sienko, A., Cichosz, A., Urban, A., Smolarczyk, R., Czajkowski, K. and Sienko, J.(2023).The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosis. Ginekol Pol. 2024.,95(7):573-583. doi: 10.5603/gpl.97573. Epub. PMID: 37768015.
Soleas, G., J, Diamandis, E., P. and Goldberg, D., M.(1997). Resveratrol: A molecule whose time has come? And gone? Clinical Biochemistry, 30(2), 91–113. https://doi.org/10.1016/s0009-9120(96)00155-5
Tan, C., Zhou, H, Wang, X., Mai, K. and He, G.(2019).Resveratrol attenuates oxidative stress and inflammatory response in turbot fed with soybean meal-based diet. Fish & Shellfish Immunology, 91, 130–135.
Tian, B. and Liu, J.(2020). Resveratrol: a review of plant sources, synthesis, stability, modification and food application. In Journal of the Science of Food and Agriculture (Vol. 100, Issue 4, pp. 1392–1404). John Wiley and Sons Ltd. https://doi.org/10.1002/jsfa.10152.
Vivar-Altamirano, F. A. and Tayupanda-Cuvi, N. J. (2024). Polifenoles y enfermedades neurodegenerativas, perspectiva desde la dieta y los suplementos. Polo del Conocimiento, 9(12), 1375-1393. https://doi.org/10.23857/pc.v9i12.8548
Wang, M., Weng, X., Chen, H., Chen, Z. and Liu, X.(2020)Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats. Acta Cir Bras. 3.,35(5):e202000506. doi: 10.1590/s0102-865020200050000006. PMID: 32638845., PMCID: PMC7341989.
Xia N, Förstermann U. and Li H.(2014). Resveratrol and endothelial nitric oxide. Molecules. 19(10):16102-21. doi: 10.3390/molecules191016102. PMID: 25302702., PMCID: PMC6270738.
Xia, Y., Zhang, H., Wu, X., Xu, Y. and Tan, Q.(2024). Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway. Biogerontology, 25(4), 649–664. https://doi.org/10.1007/s10522-024-10099-6
Xu, L., Botchway, BOA., Zhang, S., Zhou, J. and Liu, X.(2018). Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury. Front Neurosci. Oct 4.,12:690. doi: 10.3389/fnins.2018.00690. PMID: 30337851., PMCID: PMC6180204.
Yi CO, Jeon BT, Shin HJ, Jeong EA, Chang KC, Lee JE, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS. and Roh GS.(2011). Resveratrol activates AMPK and suppresses LPS-induced NF-κB-dependent COX-2 activation in RAW 264.7 macrophage cells. Anat Cell Biol. 44(3):194-203. doi: 10.5115/acb.2011.44.3.194. Epub 2011 Sep 29. PMID: 22025971., PMCID: PMC3195823.
Zhang, L., X., Li, C. X., Kakar., M. U., Khan., M. S., Wu., P. F., Amir., R. M., Dai., D. F., Naveed., M., Li, Q. Y., Saeed., M., Shen., J. Q, Rajput., S. A. and Li., J. H.(2021). Resveratrol (RV): A pharmacological review and call for further research. Biomedicine and Pharmacotherapy, 143. https://doi.org/10.1016/j.biopha.2021.112164
Zini, R., Morin, C., Bertelli, A.,A., Bertelli, A.A. and Tillement, J.P.(1999).Effects of resveratrol on the rat brain respiratory chain. Drugs under experimental and clinical research, 25 2-3, 87-97.